science

Sharks show novel changes in their immune cancer-related genes

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A new genomics study of shark DNA, including from great white and great hammerhead sharks, reveals unique modifications in their immunity genes that may underlie the rapid wound healing and possibly higher resistance to cancers in these ocean predators. This research brings us a few steps closer to understanding, from a genetic sense, why sharks exhibit some characteristics that are highly desirable by humans.

Sharks and rays are well known to be highly efficient wound healers, and suspected to show a greater resistance to cancers, though this needs further study. These properties are likely tied to their immune systems, which have been fine-tuned over 400 million years of evolution.

A study by the Nova Southeastern University (NSU) Save Our Seas Shark Research Center and Guy Harvey Research Institute (GHRI) and the Cornell University College of Veterinary Medicine just published in the journal BMC Genomics (lead author, postdoctoral associate Nicholas Marra,) now provides the first evidence that some shark and ray immunity genes have undergone evolutionary changes that may be tied to these novel immune system abilities.

“The immune system of sharks and rays has been battle-tested and evolved over hundreds of millions of years,” said Mahmood Shivji. Ph.D., director of NSU’s Save Our Seas Shark Research Center and Guy Harvey Research Institute. “Using genomics approaches to understanding their immunity genesis is likely to produce many more exciting discoveries, some of which could potentially translate into human medical benefit. Now we have another important reason to make sure we don’t lose these marvelous and ecologically critical animals to overfishing, as is currently occurring in many parts of the world. We’ve just scratched the surface in terms of learning what these ancient animals can teach us, as well as possibly provide us in terms of direct biomedical benefits.”

Cancer-related Immunity Genes

The researchers found that two shark immune genes, legumain and Bag1, stood out in particular. Both these genes have counterparts in humans, where their overexpression is well known to be associated with a whole range of cancers. Quite notably, the new research shows that these genes in sharks, however, have become modified and have undergone evolutionary natural selection.

“Several studies have demonstrated anti-tumor properties of shark-derived compounds in lab studies, said Shivji, who co-led this research with Michael Stanhope, Ph.D., of Cornell University. “It’s intriguing that we are now seeing evidence of evolutionary adaptation in these specific shark immunity genes, which just happen also to be involved in promoting cancer in humans.”

Wound-healing Related Genes

And the novelty of the shark immune system does not end there. What might explain their rapid wound healing abilities while immersed in seawater with its myriads of bacteria which would be expected to quickly cause infections in open wounds?

The shark DNA sequences provide further clues. The research team found that compared to bony fishes, the four species of sharks and ray examined not only had a much higher proportion of genes involved in antibody-mediated immunity, but also that several of the infection immunity-related genes were expressed only in the sharks and rays.

“This higher proportion of genes involved in adaptive (antibody) immunity function could be a key reason behind the infection fighting and fast wound-healing abilities of sharks and rays,” said Professor Stanhope. “Previous studies of the shark immune system have already yielded some surprises in terms of antibody structure, and these new genetic findings further add to the box of biological novelties in this highly successful vertebrate lineage.”

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