Nuclear receptors in cancer — uncovering new and evolving roles through genomic analysis


Nuclear receptors (NRs) have historically been at the forefront of cancer research, where they are known to act as critical regulators of disease. They also serve as biomarkers for tumour subclassification and targets for hormone therapy. However, most tumour types express extensive repertoires of NRs, whose interactions provide multiple paths for disease progression and offer potentially untapped mechanisms for therapeutic interventions. Recently, next-generation sequencing technologies have provided genome-wide insights into the complex interplay of NR transcriptional networks and their contribution to the development and progression of cancer. These findings have altered the traditional understanding of NR activities in oncogenesis.


  1. 1.

    Jin, Z., Li, X. & Wan, Y. Minireview: nuclear receptor regulation of osteoclast and bone remodeling. Mol. Endocrinol. 29, 172–186 (2015).


  • 2.

    Yin, K. & Smith, A. G. Nuclear receptor function in skin health and disease: therapeutic opportunities in the orphan and adopted receptor classes. Cell. Mol. Life Sci. 73, 3789–3800 (2016).

  • 3.

    Nagy, Z. S., Czimmerer, Z. & Nagy, L. Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism. Mol. Cell. Endocrinol. 368, 85–98 (2013).

  • Read More:



Add comment